MECHANISMS OF ACTION

The main effective factor is a curative breathing environment, which is saturated with dry sodium chloride aerosol at a mass concentration varying from 1-16 mg/m3 with a particle size of 1-5 um. Particle size is optimal for penetration in all sections of the respiratory tract. Dry sodium chloride aerosol has a considerable level of negative charge of the particles (6-10 nK/m3). The inner surfaces of airways have a slight positive charge. Negatively charged particles of dry sodium chloride aerosol move in the lumen of respiratory tract and settle more intensively compared to neutral particles. In addition, the negative charge increases aerosol stability. Thus dry aerosol action is much more effective than one that is moist.

The use of dry aerosol allows the creation of the optimal temperature and humidity parameters in the curative chamber, thus avoiding respiratory tract mucus edema and bronchial spasm - common reactions in patients when moist aerosols are used. Furthermore, the dose of sodium chloride received by the patient within a 1-hour Halotherapy session is less than the dose received while inhaling moist sodium chloride aerosol.

The positive effect of Halotherapy could be explained in the following way:
One of the pathogenesis mechanisms of obstructive lung diseases is the mucocellular clearance disturbance. Sodium chloride aerosol improves reological properties of the airway's content and normalizes mucocellular clearance. Sodium chloride is necessary for normal functioning of the bronchial ciliated epithelium, whereas the sodium chloride content in the bronchial secretion of patients with chronic lung diseases decreases. Due to the aerosol's curative influence, the beneficial effects in improving respiratory tract drainage function are evident during Halotherapy: relief of sputum expectoration, reduction of sputum viscosity, relief of coughing and positive changes in the auscultator picture of the lungs.

Sodium chloride aerosol provides bactericidal and bacteriostatic effect on respiratory tract micro flora and stimulates alveolar macrophage reactivity, facilitating the increase of phagocyte elements and their activity.

Cytobacteriological research of bronchial and nasopharyngeal content of patients with asthma, chronic obstructive bronchitis and cystic fibrosis demonstrate the fact that Halotherapy promotes the reduction of neutrophils and pathogenic microorganisms and increases alveolar macrophages. Its inhibitory effect on growth and vital capability of microorganisms is accompanied by loss of their pathogenic properties and by adaptation to changed conditions.

This adaptation, due to the loss of fluid, leads to the enhancement of their hydrophobic properties, facilitating attachment to epithelial cells. However, the activation of microbial adhesion does not occur due to the increase of epithelial cell's electrophysiological functional activity. Moreover, the colonization resistance of epithelial cells is enhanced under the effect of dry sodium chloride aerosol.
This indicates its favorable action on the protective properties of respiratory tract cells and activation of non-specific body defense.
Superficial skin autoflora of most of the patients normalizes after Halotherapy sessions. Halotherapy effects positively on humoral and cellular immunity of the patients with chronic lung diseases. The reduction of IgE levels after Halotherapy in patients with asthma is especially important.

Optimal temperature and humidity, hypoallergenic and hypobacterial air medium are maintained in the Halochamber. Breaking patient contact with pathogenic external air factors has an additional positive influence on the organism.

The mechanisms of action of Halotherapy are many-fold:
• mucolytic
• antibacteriologic
• antiinflammatory
• immunomodulating
• hyposensibilizing


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